Topical remedies capable of protecting skin from damage and supporting its regeneration\ncan improve skin�s health as well as its appearance. Small copper peptides have an excellent safety\nrecord and are widely used in cosmetic products. The most studied copper peptide is GHK-Cu\n(glycyl-L-histidyl-L-lysine), a small copper-binding peptide, naturally present in human plasma.\nSince its discovery in 1973, in vivo and in vitro studies have shown that GHK-Cu possesses a wealth\nof health-positive actions including improving wound contraction and epithelization, and increasing\nthe production of growth factors and activity of antioxidant enzymes. Recently, gene expression\nprofiling shed new light on diverse biological actions of GHK-Cu. The present paper discusses\nevidence of GHK-Cu and other small copper peptides possessing potent anti-cancer properties.
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